Publications

Analgesic and Anti-Inflammatory Effects of the Synthetic Neurosteroid Analogue BNN27 during CFA-Induced Hyperalgesia.

 

Poulaki S, Rassouli O, Liapakis G, Gravanis G, Venihaki M

Publication/Date/RefBiomedicines 2021, 9, 1185

Characterization of substantia nigra neurogenesis in homeostasis and dopaminergic degeneration: beneficial effects of the microneurotrophin BNN-20.

 

Mourtzi T, Dimitrakopoulos D, Kakogiannis D, Salodimitris C, Botsakis K, Meri DK, Anesti M, Dimopoulou A, Charalampopoulos I, Gravanis A, Matsokis N, Angelatou F, Kazanis I.

Publication/Date/RefStem Cell Res Ther. 2021 Jun 10;12(1):335

Characterization of substantia nigra neurogenesis in homeostasis and dopaminergic degeneration: beneficial effects of the microneurotrophin BNN-20.

 

Tsika, Tzatzarakis MN, Antimisiaris S, Tsoka P, Efstathopoulos P, Charalampopoulos I, Gravanis A, Tsilimparis M.

Publication/Date/RefPharmacol Res Perspect. 2021 Apr;9(2):e00724. doi: 10.1002/prp2.724

The beneficial role of the synthetic microneurotrophin BNN20 in a focal demyelination model.

 

Kalafatakis I, Patellis A, Charalampopoulos I, Gravanis A, Karagogeos D.

Publication/Date/RefJ Neurosci Res. 2021 Feb 13. doi: 10.1002/jnr.24809

The novel dehydroepiandrosterone (DHEA) derivative BNN27 counteracts cognitive deficits induced by the D1/D2 dopaminergic receptor agonist apomorphine in rats.

Pitsikas N, Zoupa E, Gravanis A.

Publication/Date/RefPsychopharmacology (Berl). 2021 Jan;238(1):227-237

Psychoactive properties of BNN27, a novel neurosteroid derivate, in male and female rats.

Kokras N, Dioli C, Paravatou R, Sotiropoulos MG, Delis F, Antoniou K, Calogeropoulou T, Charalampopoulos I, Gravanis A, Dalla C.

Publication/Date/RefPsychopharmacology (Berl). 2020 Aug;237(8):2435-2449

Anti-neuroinflammatory, protective effects of the synthetic microneurotrophin BNN-20 in the advanced dopaminergic neurodegeneration of “weaver” mice.

 

Panagiotakopoulou V, Botsakis K, Delis F, Mourtzi T, Tzatzarakis MN, Dimopoulou A, Poulia N, Antoniou K, Stathopoulos GT, Matsokis N, Charalampopoulos I, Gravanis A, Angelatou F.

Publication/Date/RefNeuropharmacology. 2020 Mar 15;165:107919

Neurosteroids as regulators of neuroinflammation.

Yilmaz C, Karali K, Fodelianaki G, Gravanis A, Chavakis T, Charalampopoulos I, Alexaki VI.

Publication/Date/RefFront Neuroendocrinol. 2019 Oct;55:100788.

Effect of topical administration of the microneurotrophin BNN27 in the diabetic rat retina.

Ibán-Arias R, Lisa S, Poulaki S, Mastrodimou N, Charalampopoulos I, Gravanis A, Thermos K.

Publication/Date/RefGraefes Arch Clin Exp Ophthalmol. 2019 Nov;257(11):2429-2436.

The novel dehydroepiandrosterone (DHEA) derivative BNN27 counteracts behavioural deficits induced by the NMDA receptor antagonist ketamine in rats.

Publication/Date/RefNeuropharmacology. 2019 Jun;151:74-83

The Synthetic Microneurotrophin BNN27 Affects Retinal Function in Rats With Streptozotocin-Induced Diabetes.

Publication/Date/RefDiabetes. 2018 Feb;67(2):321-333.

DHEA inhibits acute microglia-mediated inflammation through activation of the TrkA-Akt1/2-CREB-Jmjd3 pathway.

Publication/Date/RefMol Psychiatry. 2018 Jun;23(6):1410-1420.

The novel synthetic microneurotrophin BNN27 protects mature oligodendrocytes against cuprizone- induced death, through the NGF receptor TrkA.

Publication/Date/RefGlia. 2017 Aug;65(8):1376-1394.

BNN-20, a synthetic microneurotrophin, strongly protects dopaminergic neurons in the “weaver” mouse, a genetic model of dopamine-denervation, acting through the TrkB neurotrophin receptor.

 

Publication/Date/RefNeuropharmacology. 2017 Jul 15;121:140-157

The novel dehydroepiandrosterone (DHEA) derivative BNN27 counteracts delay-dependent and scopolamine-induced recognition memory deficits in rats.

Publication/Date/RefNeurobiol Learn Mem. 2017 Apr;140:145-153

Synthetic microneurotrophins in therapeutics of neurodegeneration.

Publication/Date/RefOncotarget. 2017 Feb 7;8(6):9005-9006

BNN27, a 17-Spiroepoxy Steroid Derivative, Interacts With and Activates p75 Neurotrophin Receptor, Rescuing Cerebellar Granule Neurons from Apoptosis.

 

Publication/Date/RefFront Pharmacol. 2016 Dec 26;7:512

MicroNeurotrophins Improve Survival in Motor Neuron- Astrocyte Co-Cultures but Do Not Improve Disease Phenotypes in a Mutant SOD1 Mouse Model of Amyotrophic Lateral Sclerosis.

Publication/Date/RefPLoS One. 2016 Oct 7;11(10):e0164103

Selective and differential interactions of BNN27, a novel C17-spiroepoxy steroid derivative, with TrkA receptors, regulating neuronal survival and differentiation.

Publication/Date/RefNeuropharmacology. 2016 Dec;111:266-282

Effects of novel synthetic microneurotrophins in diabetic retinopathy.

Publication/Date/RefSpringerplus. 2015 Jun 12;4(Suppl 1):L25

Dehydroepiandrosterone: an ancestral ligand of neurotrophin receptors.

Publication/Date/RefEndocrinology. 2015 Jan;156(1):16-23

Genetic dissection of neurotrophin signaling through the p75 neurotrophin receptor.

Publication/Date/RefCell Rep. 2012 Dec 27;2(6):1563-70

Neurosteroids and microneurotrophins signal through NGF receptors to induce prosurvival signaling in neuronal cells.

Publication/Date/RefSci Signal. 2012 Oct 16;5(246):pt8

The neurosteroid dehydroepiandrosterone (DHEA) protects the retina from AMPA-induced excitotoxicity: NGF TrkA receptor involvement.

Publication/Date/RefNeuropharmacology. 2012 Apr;62(5-6):2106-17

Neurosteroid dehydroepiandrosterone interacts with nerve growth factor (NGF) receptors, preventing neuronal apoptosis.

Publication/Date/RefPLoS Biol. 2011 Apr;9(4):e1001051

Dehydroepiandrosterone protects human keratinocytes against apoptosis through membrane binding sites.

Publication/Date/RefExp Cell Res. 2009 Aug 1;315(13):2275-83